Steroids in acute heart failure

Testosterone can be administered parenterally , but it has more irregular prolonged absorption time and greater activity in muscle in enanthate , undecanoate , or cypionate ester form. These derivatives are hydrolyzed to release free testosterone at the site of injection; absorption rate (and thus injection schedule) varies among different esters, but medical injections are normally done anywhere between semi-weekly to once every 12 weeks. A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system. [56] Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream. In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.

Pulse therapy involves taking high doses of glucocorticoids over a short period of time. This approach is typically used to treat acute flares, as well as a “bridge” therapy until DMARD treatment reaches full effect. Typically, pulse therapy is given as a high-dose IV infusion, for instance IV methylprednisolone 1000 mg daily for 3 consecutive days once per month. Lower doses may also be used. Although, IV infusion is the preferred route of administration for pulse therapy, steroids may also be given orally or by intramuscular injection. Patients who receive steroid pulse therapy alone may have a response that lasts 6 to 8 weeks. If given in combination with DMARD treatment, responses can last much longer. 1

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Steroids in acute heart failure

steroids in acute heart failure

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