Advances in biomedical sciences are often based on the development of new drugs which improve and save the lives of millions of patients. Drugs with specific biochemical actions are also powerful research tools. They provide pharmacologists and other biomedical scientists unique research opportunities which help to elucidate cellular signaling cascades. Students of the program will develop expertise in the fundamentals of Molecular and Cellular Pharmacology. They will be able to solve a variety of problems in basic biomedical sciences involving the design of research strategies for the discovery of novel drugs or gene therapy approaches.
The response is equal to the effect, or ( E ), and depends on both the drug binding and the drug-bound receptor then producing a response; thus, potency depends on both affinity and efficacy. The agonist, the ligand, drug or hormone that binds to the receptor and initiates the response is usually abbreviated A or D . Below a certain concentration of agonist ( [A] ), E is too low to measure but at higher concentrations it becomes appreciable and rises with increasing agonist concentration [A] until at sufficiently high concentrations it can no longer be increased by raising [A] and asymptotes to a maximum E max .