Additionally, the following adverse reactions have been identified during the post approval use of the Astelin brand of azelastine hydrochloride % nasal spray (total daily dose mg to mg). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Adverse reactions reported include the following: anaphylactoid reaction, application site irritation, facial edema, paroxysmal sneezing, tolerance, urinary retention, and xerophthalmia .
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